The shallow water equations are a mathematical tool widely applied for the simulation of flow routing in rivers and floodplains, as well as for flood inundation mapping. The interest of many researchers has been focused on the study of simplified forms of the original set of equations. One of the most commonly applied simplifications consists of neglecting the inertial terms. The effects of such a choice on the outputs of the simulations of flooding events are controversial and are an important topic of debate. In the present paper, two numerical models recently proposed for the solution of the complete and zero-inertia forms of the shallow water equations, are applied to several unsteady flow routing scenarios. We simulate synthetic and laboratory scenarios of unsteady flow routing, starting from very simple geometries and gradually moving towards complex topographies. Unlike the studies of the range of validity of the zero-inertia model, based on a small perturbation of the linearized flow model, in unsteady flow propagation over irregular topographies, it is more difficult to specify criteria for the applicability of the simplified set of equations. In analyzing the role of the terms in the momentum equations, we try to understand the effect of neglecting the inertial terms in the zero-inertia formulation. We also analyze the computational costs.