The feasibility of the multi-nucleon transfer (MNT) reaction in the 136Xe +198Pt system was investigated for synthesizing neutron-rich heavy nuclei around mass number A∼200 of astrophysical interest. Identification of the projectile-like fragments (PLF’s) was successfully performed by using VAMOS++ spectrometer. The isotopic distributions of the PLF’s produced by two-proton stripping and pickup reactions were compared with each other, demonstrating the properties of the MNT reactions observed in the present system. The two-proton pickup channels strongly populated than the twoproton stripping channels were observed. The isotopic distributions for different total kinetic energy loss (TKEL) ranges are also discussed. The overall enhancement of the strength of the two-proton pickup compared with the two-proton stripping appears to be related to the MNT reactions with relatively moderate energy dissipation.