Agri-food supply chain management (ASCM) research has gained attraction in recent years. This study aims to examine the knowledge structure, trace the evolution of, and propose future research directions for ASCM by a systematic literature review combined with bibliometric and content analyses. A total of 1770 articles were selected from Scopus for bibliometric analyses. We conducted a content analysis based on 188 articles in six clusters selected from the co-citation analysis. This review provides insights into key authors, their affiliations, journal quality, and the prestige of the reviewed articles, aspects that have not been fully captured or evaluated by previous reviews. Using bibliometric tools, we identified six clusters for ASCM, based on which, future research directions are proposed. Content analysis provides additional insights in each cluster. In particular, sustainability runs through all the themes identified except for one.