ABSTRACT Experimental studies were conducted aiming to characterize the thermal conditions in urban areas of the Brazilian semiarid for identifying the level of human thermal comfort in urban areas of the municipalities of Mossoró-RN, Serra Talhada-PE, Petrolina-PE and Juazeiro-BA. The results showed that the constituent elements of urban areas contribute to human thermal discomfort index (DIT). Both the wet and dry seasons showed up an uncomfortable condition in Mossoró on May 15th and on 23rd, 2008 (rural area) and on May 25rd, 2008 (urban area). By applying Thom's equation for obtaining the DIT, it was observed that the urban areas reported thermal comfort conditions always inferior to those observed in the rural areas. The results indicate conditions of partial comfort for the all areas surveyed. However, the incidence of human thermal discomfort related to the minimum, average and maximum air temperatures are, probably associated to the formation of urban heat islands. In addition, the afforestation is an effective mechanism of mitigating the adverse effects of these structures with better quality of life to the population. Therefore, it can be stated that the Brazilian semiarid region has specific urban climate, which is influenced by the design characteristics of the urban structure and buildings.