Objective: To analyze the syndrome characteristics in patients with chronic persistent asthma. Methods: 365 patients (121 males, 244 females, 60.8 ± 29.1 years old) with chronic persistent asthma were enrolled in this cross-sectional study. The information of syndrome, symptoms, signs, tongue coating and pulse were collected from all patients. The syndrome characteristics of chronic persistent asthma were examined through the multifactor dimensionality reduction (MDR) analysis and the results were verified by the Chi-square test. Results: The results of the MDR analysis and the Chi-square test showed the following positive correlation of the interaction among: the deficiency syndrome of the lung and spleen and deep pulse, disinclination to talk due to lack of qi, fatigue, lassitude and thick tongue coating; the deficiency syndrome of the lung and kidney and dizziness and disinclination to talk due to lack of qi, fatigue, lassitude and pallid complexion; the syndrome of phlegm-heat obstructing the lung and rapid pulse, abdominal distension, disinclination to talk due to lack of qi, frequent urination and lassitude; the syndrome of phlegm-dampness obstructing the lung and disinclination to talk due to lack of qi, greasy coating, fatigue and lassitude. (P < .05 for all). Conclusion: The syndrome of chronic persistent asthma is characterized by fatigue and lassitude due to dysfunction of the lung, spleen and kidney.