A cascaded intensity modulator (IM) and phase modulator (PM) are used to modulate a continuous-wave (CW) laser and generate an optical frequency comb (OFC). Thus, the generated comb is utilized as an initial seed and combined with another CW-laser to generate four-wave mixing (FWM) in photonic crystal fiber (PCF). Results show that an initial flat 30 GHz OFC of 29, 55 lines within power fluctuation of 0.8 dB and 2 dB, respectively, can be achieved by setting the ratio of the DC bias to amplitude of sinusoidal signal at 0.1 and setting the modulation indices of both IM and PM at 10. Moreover, the 1st order of FWM created through 14 m of PCF has over 68 and 94 lines with fluctuation of 0.8 dB and 2 dB, respectively. Hence, the generated wavelengths of 1st left and right order of FWM can be tuned in a range from ~1500 nm to ~1525 nm and ~1590 nm to ~1604 nm, respectively.