The Republic of Rwanda is located in the Great lakes region of the central Africa. This landlocked country has historically suffered from periodic natural and manmade disasters, mainly in the form of droughts, floods and landslides impacting the agrarian economy and the country’s efforts towards sustainable development and poverty reduction. Vulnerability to Periodic natural disasters is a long term concern. The study therefore aims at conducting an assessment of disaster risks, vulnerabilities and coping capacities in Burera, Nyabihu and Musanze Districts affected floods and landslides in order to put in place mitigation strategies for disaster risks. Different methods and techniques were used to conduct this study including interviews, questionnaires, focus group discussions, field visits and observations, GIS and remote sensing among others. The analysis comprised the disaggregation of the hazards’ characteristics including description of the hazard, Triggering factors, Frequency, seasonality, Duration, sectors affected, impacts, time of recovery, intensity of the hazard and others. In terms of vulnerability. The analysis comprised physical, environmental, social, institutional, economic, profile of the most vulnerable populations, differentiation of impacts, and level of vulnerabilities. The study results showed that the Disaster Risk reduction is very possible through a comprehensive risk management. There is also a big need to expand capacity building in terms of disaster management, risk mapping to reach cell and village levels, put in place and operationalize early warning systems or hydro-meteorological hazards and many others in order to minimize the disaster risks and where possible to transform them into opportunities. All disasters are not preventable but mitigation is always possible.