Dissimilar joining of Ti3Al-based alloy to Ni-based superalloy has been carried out using gas tungsten arc (GTA) welding technology with Ti–Nb and Ti–Ni–Nb filler alloys. The joint welded with the Ti–Nb filler alloy contained much less interfacial brittle phases than the one using the Ti–Ni–Nb filler alloy. The average room-temperature tensile strength of the joint welded with Ti–Nb was 202 MPa and the strength value of the one welded with Ti–Ni–Nb was 128 MPa. For both fillers, the weak links of the dissimilar joints were the weld/In718 interfaces. The presence of TiNi, TiNi3 and Ni3Nb intermetallic compounds in the joint welded with Ti–Ni–Nb induced microcracks at the weld/In718 interface and deteriorated the mechanical properties of the joint. And the adoption of the Ti–Nb filler alloy decreased the formation tendency of interfacial brittle phases to some extent and thus enhanced the tensile strength of the joint.