Accurate monitoring of land surface dynamics using remote sensing is essential for the synoptic assessment of environmental change. We assessed a Medium Resolution Imaging Spectrometer (MERIS) full resolution dataset for vegetation monitoring as an alternative to the more commonly used Moderate-Resolution Imaging Spectroradiometer (MODIS) data. Time series of vegetation indices calculated from 300 m resolution MERIS and 250 m resolution MODIS datasets were analyzed to monitor vegetation productivity trends in the irrigated lowlands in Northern Uzbekistan for the period 2003–2011. Mann-Kendall trend analysis was conducted using the time series of Normalized Differenced Vegetation Index (NDVI), Soil-Adjusted Vegetation Index (SAVI), and MERIS-based Terrestrial Chlorophyll Index (MTCI) to detect trends and examine the capabilities of each sensor and index. The methodology consisted of (1) preprocessing of the original imagery; (2) processing and statistical analysis of the corresponding time series datasets; and (3) comparison of the resulting trends. Results confirmed the occurrence of widespread vegetation productivity decline, ranging from 5.5% (MERIS-MTCI) to 21% (MODIS-NDVI) of the total irrigated cropland in the study area. All indices identified the same spatial patterns of decreasing vegetation. Average vegetation index values of NDVI and SAVI were slightly higher when measured by MERIS than by MODIS. These differences merit further investigation to allow a fusion of these datasets for consistent monitoring of cropland productivity decline at scales suitable for guiding operational land management practices.