Background: Low circulating IGF-1 and high hs-CRP may be associated with cardiovascular diseases. Hence, it is an important question that is there any correlation between these important biomarkers? Since the correlation between IGF-1 and hs-CRP has not been adequately investigated, the main aim of this study was to evaluate the association between these biomarkers among postmenopausal women. Materials and Methods: A total of 361 healthy Iranian postmenopausal women were randomly selected in a population-based study. The metabolic syndrome was defined according to NCEP, ATPIII criteria. Circulating hs-CRP and IGF-1 levels were measured by highly specific enzyme-linked immunosorbent assay method. Results: Women with higher than median hs-CRP levels had lower IGF-1 levels, in comparison to women with lower than median hs-CRP levels (p<0.0001). In multiple regression analysis, after adjustment for age and the metabolic syndrome, IGF-1 levels had a significant inverse correlation with circulating hs-CRP levels (β=-0.139, p<0.007). After adjustment for age, body mass index and type 2 diabetes mellitus, IGF-1 levels also showed an inverse correlation with hs-CRP levels (β=-0.130, p<0.014). Conclusion: There is a significant inverse correlation between serum IGF-1 and hs-CRP levels in postmenopausal women. This finding provides evidence of the potential cardioprotective effect of IGF-1 via anti-inflammatory mechanisms.