This paper contains a discussion of curricular implications of interdisciplinary education and pedagogical strategies. The focus of the literature cited in this work is on application activities aimed at developing critical thinking, creativity, collaboration and communication to prepare students to meet the challenges of the 21st century. The Know/Do/Be conceptual model for interdisciplinary education, the pros and cons of interdisciplinary education, and pedagogies that lend themselves well to interdisciplinary strategies, such as Inquiry-Based Learning and Team-based Learning, and instructor competencies are examined.