Background & Aims: Job adaptability is essential to the successful employment of nurses, which could be largely influenced by psychological capital. The present study aimed to investigate the association between psychological capital and job adaptability in the nurses at Kashan University of Medical Sciences hospital, Iran. Materials & Methods: This descriptive-correlational study was conducted on 190 nurses at Kashan University of Medical Sciences hospital, who were selected via stratified random sampling. Data were collected using two questionnaires of psychological capital and job compatibility. Data analysis was performed in SPSS version 22 using descriptive and inferential statistics.   Results: The mean psychological capital (5.41±0.77) was above average 4, and the mean job compatibility (3.23±0.43) was above average 3. Pearson's correlation-coefficient indicated a positive, significant correlation between psychological capital and job adaptability of nurses (r=0.43). In addition, the most significant association was observed between psychological capital and value orientation (r=0.43), while the least significant correlation was denoted between psychological capital and autonomy (r=0.15). Conclusion: According to the results, the implementation of programs for the improvement of psychological capital in the nursing community could result in the job adaptability of nurses. Furthermore, a supportive view within hospitals toward nurses and the subsequent perception of being supported on behalf of nurses could effectively enhance their job adaptability.