síntese e atividade antibacteriana de imidas cíclicas: 3,4-dicloromaleimidas e 3-cloro-4-substituída-maleimidas
;Andricopulo Adriano Defini;Yunes Rosendo Augusto;Nunes Ricardo José;Savi Alessandro O. S.;Corrêa Rogério;Cruz Alexandre Bella;Cechinel Filho Valdir
greece and rome1998Vol. 21pp. 573-577
93
defini1998qumicasntese
Abstract
In the present study, new N-aryl and N-alkylarylcyclic imides were synthesized and their antibacterial properties against Escherichia coli and Staphylococcus aureus were evaluated by using the diffusion method. All compounds were obtained in good yield (54 - 95%) and characterized by spectral data (¹H-NMR, MS, IR) and elemental analysis (CHN). The biological results indicated that some compounds exert significative antibacterial effects, confirming previous studies on biological activities of cyclic imides.