Teenagers commonly use cannabis. Expectancies related to the effects of cannabis play an important role in its consumption and are frequently measured with the Marijuana Effect Expectancies Questionnaire (MEEQ). This study aims to assess the psychometric properties (factor structure, internal consistency reliability, criterion validity) of the French MEEQ. A sample of 1,343 non-clinical teenagers (14–18 years) were recruited to answer a self-report questionnaire; 877 of them responded twice (one-year interval). A four-factor structure was obtained: Cognitive Impairment and Negative, Relaxation and Social Facilitation, Perceptual Enhancement and Craving and Negative Behavioral Effect Expectancies. It is concluded that the French MEEQ constitutes an appropriate tool to measure cannabis effect expectancies among adolescents.