In this study, Khadiraristha (KDR), a traditional Ayurvedic preparation used in dennatological disorder has been in-vestigated for its biochemical effects and in some extent justify the pliannacological uses under the stated circums-tances. Kliadiraristlia was administered orally to female albino rat for 46 days. After the treatment period animals were fasted for 18 hours. Biochemical parameters including; Total protein. Serum albumin. Blood Urea Nitrogen, Bilirubin. Liver enzymes (sGPT, sGOT, ALT) were detennined in the plasma. KDR significantly inereased (p)