The production and consumption of muskmelon have been increasing (MELO et al., 2014), thus, information on techniques for higher field productions are necessary. The experiment described in the present work was conducted in the IFTM, Uberaba, State of Minas Gerais, Brazil, aiming to evaluate the muskmelon yield under different soil water tensions. A randomized block experimental design was used with five treatments (soil water tensions of 10, 20, 30, 40 and 50 kPa) and four replications (plots of two rows of 14 plants). Two harvests were carried out and the fruit yield, stem diameter, number of fruits per plant and efficiency of water use were evaluated. Irrigation was performed with a drip irrigation system and managed with tensiometry. The cultivar Bonus n.2 was used with spacing of 1.0 x 0.6 m. The data of the variables were subjected to the F test and regression test. The treatments showed statistical differences in number of fruits per plant, fruit weight (fruit yield) and stem diameter. The highest fruit yield found was 1.36 kg fruit-1 and the highest water use efficiency was 4.08 g mm-1 with irrigation for a soil water tension of 10 kPa. The lowest fruit yield was found with irrigation for a soil water tension of 50 kPa.