The purpose of this experimental study is to study the patterns of morphological response of the abdominal wall tissues to the implantation of a combined (xenopericardial plate and polyester mesh) hernia prosthesis. Material and Methods. The experiment was carried out on fifteen rabbits of the breed Chinchilla weighing up to 3.5kg. The combined prosthesis was implanted intra — abdominally. The animals were withdrawn from the experiment after 2 weeks, 1 month and 2 months. After the beginning of the study morphological and morphometric assessment of the tissue state in the implantation zone of the prosthesis was carried out. Results. The combined hernia prosthesis when implanted into the anterial abdominal wall causes a rather pronounced inflammatory reaction, progressing within a month after the operation. By the second month of the experiment, signs of inflammation decrease. In this case, active growth of the young connective tissue in the implant from the side of the polyester mesh occurs. Xenopericardial plate, facing the abdominal cavity with a smooth side does not cause the formation of connective tissue, which protects the abdominal cavity from the occurrence of adhesions in the postoperative period. Conclusion. The use of combined hernia prosthesis for implantation into the abdominal wall allows avoiding a number of complications which often occur when using prostheses of other types.