The role of coping in the relationship between spiritual wellbeing and depression amongst ministers. The aim of this study was to determine the role of coping in the relationship between spiritual well-being and depression among ministers. The research group consisted of 53 Dutch Reformed ministers, all serving in the Northern Cape. Coping was measured by means of the Coping Orientation to Problems Experienced Questionnaire (Carver, Scheier & Weintraub 1989), spiritual well-being by means of the Spiritual Well-being Questionnaire (Gomez & Fisher 2003:1977), and depression by means of the Beck Depression Inventory-II (Beck, Steer & Brown 1996:1−2). The results of this study indicated that problem-focused coping and emotion-focused coping showed no direct relationship with depression. Problem-focused coping also plays no significant role in the relationship between spiritual well-being and depression. Emotion-focused coping, however, plays a role in the relationship between environment-related spiritual well-being and depression. Significant negative relationships between spiritual well-being and depression were found. A significant positive relationship was found between dysfunctional coping and depression. Dysfunctional coping was identified as a mediator in the relationship between personal spiritual well-being and depression. The results of this study are supported by the literature.