Antibiotic associated manic episodes, "antibiomania", have been previously documented in the literature. In a recent review of antibiomania , twelve different anti-bacterial agents were implicated. Among them, antituberculous agents, macrolides, and quinolones were the most common treatments. However, causal links and the pathophysiological mechanism of antibiomania remains elusive. Clarithromycin seems to be the antibiotic most frequently associated with antibiomania, followed by ciprofloxacin and ofloxacin. Antibiomania has also been related to treatment of Helicobacter Pylori.