This paper introduces the milk-run schema into the express distribution logistics through the feasibility analysis of application of cyclic goods-taking schema in the express industry. In order to reach fully loaded as far as possible in distribution, the article improves the traditional model, adopting multi-objective decision and conforming constraint conditions to Milk-run schema, even approximating the practical truth solves model through the C-W saving algorithm. It can effectively shorten the distance and Lower costs by means of reasonable route planning. Finally, the paper has verified the model and its effectiveness of arithmetic application by means of cases analysis.