3-(4-fluorophenyl)-<em>n</em>-[4-(4-furan-2-yl-1-oxo-2,3,7-triazaspiro[4.5]dec-3-en-2-yl)phenyl]propionamide hydrochloride

3-(4-fluorophenyl)-<em>n</em>-[4-(4-furan-2-yl-1-oxo-2,3,7-triazaspiro[4.5]dec-3-en-2-yl)phenyl]propionamide hydrochloride

;Badiadka Narayana;Balladka Kunhanna Sarojini;Seranthimata Samshuddin;Rajagopalan Srinivasan
journal of chemical sciences 2012 Vol. 2012 pp. M771-
154
narayana2012molbank3-(4-fluorophenyl)-&lt;em&gt;n&lt;/em&gt;-[4-(4-furan-2-yl-1-oxo-2,3,7-triazaspiro[4.5]dec-3-en-2-yl)phenyl]propionamide

Abstract

A simple and novel route for the synthesis of new spirocyclic propionamide derivative is developed. The present work involves <em>N</em>-arylation of pyrazolone (<strong>1</strong>) using copper(I) iodide catalyst followed by reduction to give amine (<strong>2</strong>). The coupling of <strong>2</strong> with 3-(4-fluorophenyl)propionic acid and deprotection of Boc group yields the title compound (<strong>3</strong>).

Citation

ID: 179384
Ref Key: narayana2012molbank3-(4-fluorophenyl)-&lt;em&gt;n&lt;/em&gt;-[4-(4-furan-2-yl-1-oxo-2,3,7-triazaspiro[4.5]dec-3-en-2-yl)phenyl]propionamide
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179384
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