The authors studied the clinical features of the infant with cerebral ischemia, hepatosplenomegaly and combined forms of perinatal pathology. Found the relationship between the pathological conditions of the early neonatal period and neonatal infections. In a survey of 224 infants participated maternity hospital № 2 in Krasnoyarsk. PCR method was studied serum of these children for the detection of DNA Chlamydia trachomatis, Mycoplasma genitalium, Ureaplasma sp., Cytomegalovirus and Herpes simplex type 1 and 2. Proved the highest rate of infection of children with combined perinatal diseases (48.6%) compared with children with cerebral ischemia (33.3%) and hepatosplenomegaly (36.8%). In this case, in healthy children of the control group data pathogens were detected.