The nasopalatine duct cyst (NPDC) is the most common non-odontogenic, epithelial cyst occurring in the maxilla, and it arises from the epithelial remnants of the nasopalatine duct. It accounts for approximately 2% of all maxillary cysts. A 44-year-old man presented with an asymptomatic swelling in the upper vestibular gingiva and hard palate. Computed tomography confirmed these findings, revealing a cystic mass in the midline of the maxilla that superiorly extended along the nasal septum and inferiorly along the floor of the nasal cavity. It had a maximum diameter of 42 mm. The cyst was treated by cystectomy and bilateral fenestration surgery of the nasal cavity under general anesthesia. The patient had no postoperative complications and showed no evidence of stenosis of the opening or infection in the cavity 6 months after surgery. Keywords: Nasopalatine duct cyst, Non-odontogenic epithelial cyst, Cystectomy, Fenestration surgery