Open ecosystems in Mexico are under increasing pressure, due particularly to the expansion of cities and agricultural activities. These developments occur without integrating biodiversity concerns in land use planning and result in extensive fragmentation and transformation of the landscapes. The semiarid region of Mesa Central was characterized using ten precipitation-based indices. Using multivariate statistical and geostatistical spatial analysis techniques, the influence of those indices on five land use strata was explored. Land use analysis indicated that the maximum values of the five significant precipitation-based indices were found in Grasslands, Agricultural Use, and Shrubs; minimum values were characteristic of substrates Secondary Desert Vegetation and Other Use. Our results suggest that the greatest number of extreme precipitation events is likely to occur in open ecosystems and consequently will have a strong influence on landscaping and land use. The semivariogram analysis and geostatistical layers demand attention from research institutions, policy makers, researchers, and food producers to take the appropriate and coordinated actions to propose scenarios to deal with climate change. Perhaps this study can stimulate thought concerning research endeavours aimed at promoting initiatives for biodiversity conservation and planning programs for climate change mitigation.