an alternative route for the synthesis of (e)-(+)-5(s)-methylhept-2-en-4-one (filbertone)
;Zarbin Paulo H.G.;Yonashiro Massami;Perissini Jr Waldir
british journal of dermatology1998Vol. 9pp. 583-585
85
h.g.1998journalan
Abstract
We are reporting an alternative methodology to prepare (+)-Filbertone (1), a natural flavor isolated from hazelnut extracts. Commercially available (-)-2(S)-methylbutan-1-ol (2) was used as starting material and the synthesis was carried out in four steps with an overall yield of 42%. The optical rotation and the enantiomeric purity of the final compound were determined.