an alternative route for the synthesis of (e)-(+)-5(s)-methylhept-2-en-4-one (filbertone)

an alternative route for the synthesis of (e)-(+)-5(s)-methylhept-2-en-4-one (filbertone)

;Zarbin Paulo H.G.;Yonashiro Massami;Perissini Jr Waldir
british journal of dermatology 1998 Vol. 9 pp. 583-585
85
h.g.1998journalan

Abstract

We are reporting an alternative methodology to prepare (+)-Filbertone (1), a natural flavor isolated from hazelnut extracts. Commercially available (-)-2(S)-methylbutan-1-ol (2) was used as starting material and the synthesis was carried out in four steps with an overall yield of 42%. The optical rotation and the enantiomeric purity of the final compound were determined.

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ID: 174614
Ref Key: h.g.1998journalan
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