Objective: This study aimed to predict coping strategies based on the characteristics of the stimulants-dependent people. Method: The research method was correlational. The population consisted of all stimulant-dependent individuals (n=402) that consecutively admitted to addiction centers of Tehran over the last year and had a drug dependence diagnosis. By systematic sampling, 201 subjects were selected of this population. The NEO personality inventory (NEO-FFI short form) and Lazarus-Folkman’s coping strategies (WCQ-short form) questionnaires administered among selected sample. Results: The results showed that there is a positive correlation between the personality dimension of neuroticism and coping strategies of avoidance, disengagement, and a negative one with continence. There is a positive correlation between the personality dimension of extroversion and avoidance, seeking social support and a negative one with (assuming) responsibility. Also there is a positive correlation between the personality dimension of compatibility with restraint coping strategies and seeking social support. Conscientiousness personality dimension did not predict any coping strategies in stimulus-dependent patients. Conclusion: Personality traits can predict coping strategies in stimulus-dependent individuals. For the treatment of addicted patients paying attention to evaluation of the patients’ characteristics is suggested.