Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from .
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Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from .

Otsuki, Kouharu;Li, Wei;Miura, Kasumi;Asada, Yoshihisa;Huang, Li;Chen, Chin-Ho;Lee, Kuo-Hsiung;Koike, Kazuo;
Journal of natural products 2020
230
otsuki2020isolationjournal

Abstract

Five new [daphneodorins D-H (, , and -)] and seven known daphnane diterpenoids (- and -) were isolated from . The structures of the new compounds were elucidated by extensive physicochemical and spectroscopic analysis. The isolated compounds were evaluated for their anti-HIV activity against HIV-1 infection of MT4 cells. Nine daphnane diterpenoid orthoesters (-) showed potent anti-HIV activity with EC values of 1.5-7.7 nM.

Keywords

structural elucidation mapk cytotoxic activity apiaceae ferula sinkiangensis k.m.shen sesquiterpene coumarin

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DOI:
10.1021/acs.jnatprod.0c00540

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ID: 171929
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