Tensile and fatigue testing results of D357 and B201 aluminum alloy aerospace castings reported in the literature have been reanalyzed. Yield strength–elongation bivariate data have been used as a measure of the structural quality of castings, and converted into quality index. These results as well as fatigue data have been analyzed by using Weibull statistics. A distinct relationship has been observed between expected fatigue life and quality index. Moreover, probability of survival in fatigue life was found to be directly linked to the proportions of the quality index distributions in two different regions, providing further evidence about the strong relationship between elongation, i.e., structural quality and fatigue performance.