Background: Physical and mechanical properties are important during the selection of materials which is used for root repair and root end filling to ensure their success and longevity. Aim: The aim of this study is to compare the compressive and diametral tensile strengths and solubility of Biodentine and ProRoot Mineral Trioxide Aggregate (MTA). Material & Methods: Cylindrical samples of tested materials were constructed for compressive and diametral tensile strength. After then, it was immersed in distilled water for 24 hours or 21 days at 37oC before testing. Solubility was determined by preparing discs of each material, and then stored in 50ml distilled water at 37°C for 1, 7, and 21 days. Solubility was measured as the difference between the initial weight and the weight at the end of each storage period. Results were analyzed using One-way ANOVA, Student’s t-test, and Tukey’s HSD post-hoc test (P<0.05). Results: Biodentine showed significantly higher compressive and diametral tensile strength values compared with MTA after 1 day (P<0.01). Strength values of Biodentine significantly decreased after 21 days compared with day 1 (P<0.01). On the other hand, MTA showed a significantly higher diametral tensile strength after 21 days compared with day 1 (P<0.01). Biodentine showed higher solubility than MTA (P<0.05). In addition, the solubility of Biodentine and MTA significantly decreased after 21 days compared with 1 day (P<0.01). Conclusion: Although Biodentine showed higher initial strength than MTA, the values were not significantly different after 21 days. Biodentine was more soluble than MTA.