Purpose: to examine the state rate parameters of cerebral and ocular vessels in patients with glaucoma combined with myopia of high degree.
Methods: the study involved 3 groups of patients aged 16-32 years: 1st — 30 patients (60 eyes) — with a stationary myopia of 6.5 to 9.0 D and normal intraocular pressure (IOP); 2nd — 23 patients (46 eyes) — with a high degree of progressive myopia and glaucoma with normalized intraocular pressure during instillation Azopt included 2 subgroups: subgroup A — 14 patients (28 eyes) — with ischemic variant of glaucoma; subgroup B — 9 patients (18 eyes) — with dyscirculatory variant of glaucoma; 3rd group (control) — 10 somatically healthy individuals of similar age. Following a standard ophthalmic examination techniques, as well as color Doppler mapping of the main arteries of the brain and the eyeball on the unit Acuson 128 HR/10 (USA) and hypocapnic (with O2) and hypercapnic (CO2) probe.
Results: In subgroup 2A patients showed significant (p <0.05) decrease in Vs in the central retinal artery and short posterior cili- ary arteries respectively 38.0% and 32.8% and increase the resistance index (RI) of vessels in 21.8% and 22.6%, increase Vs in the middle cerebral artery (MCA) at 11.5% and RI by 11.8% compared to the patients the third and first groups, with а hypocapnic test Vs in the MCA decreased by 35.4%, and increased with hypercapnic test for 23.0%; of the subgroup B in central retinal vein to 33.9% and 19.6%, lower Vs and RI in the vertebral artery (VA) by 20,0% and 9,1% respectively, with a hypercapnic test Vs in the MCA increased by 32.2%, and decreased during hypocapnic sample at 26.0%.
Conclusion: the predominance of the ability of MCA to vasoconstriction combined with reduced blood flow in central retinal artery and short posterior ciliary arteries and cause ischemica variant of glaucoma, slowing blood flow in the vertebrobasilar basin combined with a reduction of venous outflow of the of the eyeball and is accompanied by the development of glaucoma in dyscirculatory variant in patients with high degree of myopia.