Objective: To know the dimension of spirituality in the confrontation of patients submitted to chemotherapy. Methods: This was a descriptive, transversal and exploratory study with a qualitative approach performed with 15 patients submitted to chemotherapy in a public hospital institution of both sexes, over 18 years of age. A semi-structured interview was used, with open questions, whose answers were recorded, transcribed and organized through the Discourse of the Collective Subject. Results: The results revealed that the feelings are varied, dividing up into optimistic feelings, mostly, as well as negative ones. Conclusion: Spirituality/religiosity exerts significant influence during the chemotherapy treatment, contributing to the person passing through this moment with more optimism.