Construction projects are complex systems that inherently contain complex interface problems. This study explored the root causes of interface problems in construction projects using structural equation modeling. This technique is a systematic approach that combines factor analysis and path analysis to investigate the causal relationships among multidimensional factors. The literature on construction interface problems was reviewed, and a questionnaire survey was conducted in Taiwan to identify 27 initial factors that cause interface problems in three dimensions: owner, design, and construction. Then, a series of structural equation models (SEMs) was developed to further explore the root causes of the interface problems and their causal relationships. This study has three main findings: (1) poor design causes interface problems; (2) ineffective communication and coordination among the owner, design, and construction dimensions are the main factors that cause construction interface problems; and (3) a lack of communication and coordination has a greater influence on the construction dimension than on the owner and design dimensions. The above findings can be used as important references and sustainable management strategies for academia and decision-makers in the construction industry.