Vanishing bone disease also known as Gorham′s disease, massive osteolysis, and phantom bone disease is a rare entity characterized by spontaneous or posttraumatic progressive resorption of bone. It is a rare idiopathic disease leading to extensive loss of bony matrix, which is replaced by proliferating thin-walled vascular channels and fibrous tissue. Most often diagnosis of vanishing bone disease is based on clinical examination, radiologic imaging, and histopathologic examination of the affected area. Very few cases have been reported in Indian literature considering the rarity of the disease occurring in the jaws; we report a rare case of vanishing bone disease of hemimandible in a 65-year-old male patient.