Introduction: The aim of the study was to propose the Clinical Inventory of Sleep Quality (CISQ), and compared it with the Pittsburgh sleep quality index (PSQI). Methods: We studied 400 subjects with the CISQ. Cronbach’s alpha coefficient was calculated to measure the reliability, and to determine the concurrent validity, a Canonical correlation analysis was performed. At next, we used an exploratory and confirmatory Factorial analysis with Varimax rotation for validity construct calculation. Results: Cronbach alpha coefficient of the scale was significantly strong (α=0.81). Canonic correlation was=0.93, suggesting that data proved that the CISQ and PSQI are measuring identical subject. Confirmatory Factorial analysis model grouped items of the scale in four factors: 1. Daytime symptoms, 2. Nocturnal symptoms, 3. Sleep disordered breathing symptoms, and 4. Sleep-related movement disorders symptoms. We proposed five categories to score CISQ in a range of 0–52 points, as follows: Good quality of sleep, Mild bad sleep quality, Moderate bad sleep quality, Severe bad sleep quality, and Profound bad sleep quality. Conclusion: CISQ is a promising tool to measure sleep quality and deserve more research to confirm its utility.