Aims and Objectives: To compare the frequency of complications of laparoscopic repair of incisional hernia between polyester and Polytetraflouroethylene meshes. Materials and Methods: This study was conducted as part of an Interventional multicentre trial at the Rehman Medical Institute Peshawar, Peshawar Institute of Medical Sciences and Pakistan Institute of Medical Science Islamabad from the 1 st of October, 2008 till 30 th September, 2011. The frequency of complications was calculated as the measure of comparing two commercially available meshes for the laparoscopic repair of incisional hernia using the Intrperitoneal placement of mesh (IPOM) technique. These patients were admitted via the out-patient department and their demographic data was collected on a proforma. The size of the defect was evaluated clinically or radiologically and if >10cm were excluded from the study. Forty five patients were alternately placed in either group and group I comprised patients with a ventral hernia that was repaired with composite polyester mesh (Parietex R ) whereas the other group was also repaired laparoscopically but repaired with a Polytetraflouroethylene (Dual R ) mesh. All data was collected on the individual proforma of each patient and was loaded on the SPSS R version 13.0. Results: The BMI (body mass index) in both groups was similar ( P = 1.41). The mean hospital stay was higher in the Polytetraflouroethylene (PTFE) mesh group but the values were not significant ( P = 1.12). No peri-operative death was observed in either group. Five patients (11.11%) from group I were re-admitted with varying complaints and were diagnosed as having sub-acute intestinal obstruction ( P = 0.04). A higher but insignificant recurrence rate was observed in the polyester group over a one year period of follow up. Four patients (8.8%) that were diagnosed with recurrences in group I. Instead the PTFE group had a lower recurrence ( P = 0.91). Conclusion: The frequency of recurrence was similar in both groups. A higher frequency of intestinal obstruction was observed in the polyester group.