We propose strategies to achieve a high-throughput FPGA architecture for quasi-cyclic low-density parity-check codes based on circulant-1 identity matrix construction. By splitting the node processing operation in the min-sum approximation algorithm, we achieve pipelining in the layered decoding schedule without utilizing additional hardware resources. High-level synthesis compilation is used to design and develop the architecture on the FPGA hardware platform. To validate this architecture, an IEEE 802.11n compliant 608 Mb/s decoder is implemented on the Xilinx Kintex-7 FPGA using the LabVIEW FPGA Compiler in the LabVIEW Communication System Design Suite. Architecture scalability was leveraged to accomplish a 2.48 Gb/s decoder on a single Xilinx Kintex-7 FPGA. Further, we present rapidly prototyped experimentation of an IEEE 802.16 compliant hybrid automatic repeat request system based on the efficient decoder architecture developed. In spite of the mixed nature of data processing—digital signal processing and finite-state machines—LabVIEW FPGA Compiler significantly reduced time to explore the system parameter space and to optimize in terms of error performance and resource utilization. A 4x improvement in the system throughput, relative to a CPU-based implementation, was achieved to measure the error-rate performance of the system over large, realistic data sets using accelerated, in-hardware simulation.