The aim of the article is a comprehensive study of issues of regulation of the domestic market under conditions of changing foreign economic priorities of the public policy. By analyzing, systematizing and summarizing scientific works of many scientists, new approaches to the formation and implementation of effective mechanisms of state regulation of the domestic market at a critical stage in the modernization of the national economy are considered. As a result of the research, peculiarities of the development of the domestic market under conditions of changing priorities in the trade policy of countries are revealed. The correlation between the capacity of the domestic market and the volumes of foreign trade is analyzed. It is substantiated that under conditions of changing foreign economic priorities of the public policy, an important factor in the development of the domestic market of Ukraine is to ensure its technological competitiveness. The need to apply measures on accelerating technological growth and strengthening the fight in the global competition through the optimal combination of the effective state regulation of the domestic market and market mechanisms is proved. The prospect for further research in this direction is defining strategic objectives of the public policy regarding the institutional provision of competitiveness of Ukraine.