In this paper a regression model based for tuning proportional integral derivative (PID) controller with fractional order time delay system is proposed. The novelty of this paper is that tuning parameters of the fractional order time delay system are optimally predicted using the regression model. In the proposed method, the output parameters of the fractional order system are used to derive the regression function. Here, the regression model depends on the weights of the exponential function. By using the iterative algorithm, the best weight of the regression model is evaluated. Using the regression technique, fractional order time delay systems are tuned and the stability parameters of the system are maintained. The effectiveness and feasibility of the proposed technique is demonstrated through the MATLAB/Simulink platform, as well as testing and comparison using the classical PID controller, Ziegler–Nichols tuning method, Wang tuning method and curve fitting technique base tuning method.