Applying a holistic, integrated and experiential approach, this paper analyses the culture of head, heart and hands learning as both a challenge and an imperative of contemporary education using the descriptive method based on a review of relevant literature. Selfdetermination, self-work, self-organization and self-management are emphasized along with different models of learning culture oriented towards student’s holistic development. In accordance with that the paper discusses issues related to the new organization of learning and teaching and the role of the teachers, students and school community. Specifically, many scientists believe (Henting, 1997; Bruner, 2000; Stoll & Fink, 2000; Faulstich, 1999) that high-quality and successful changes in education can be achieved by introducing a culture of learning which espouses the holism and integrity of human beings. Such changes are especially relevant in the context of lifelong learning which integrates all three domains of learning: cognitive (head), affective (heart) and practical (hands). In this way, cognitive, affective, experiential and active learning interests are fully expressed, which bears witness to the fact that people learn, think, feel and act differently.