Four sections of senior Honors Human Anatomy and Physiology (A&P) students are representative of sixty-five nations. These classes participated in a yearlong investigation pursuant of innovative learning, and grading modalities to introduce a 21st century curriculum for A&P to become a College Board Advanced Placement (AP) course. All enrollees began the year by taking a self-assessment based on Howard Gardner's Multiple Intelligences. This data was evaluated for the design of learning approaches identifying student uniqueness that could better implement the Next Generation Science Standards (NGSS), and present State of Tennessee Human Anatomy and Physiology Learning Standards laying the groundwork to write the AP curriculum. Component curriculum rubrics were used, and modified to enable students to self-evaluate their performance in certain areas. Students participated in teams represented as Center for Disease Control and Prevention (CDC) 'Intern Teams' investigating various diseases. The students, also, researched health equity, and disparity issues from variables based on survey questions they designed that could affect the health care treatment of patients suffering from their investigated disease. They then proposed a 2016 CDC Educational Campaign revamping public health education for the disease, including brochure, and public service announcement (PSA).