Glyphosate-based herbicides are the dominant products used internationally for control of vegetation in planted forests. Few international, scientific syntheses on glyphosate, specific to its use in planted forests, are publically available. We provide an international overview of the current use of glyphosate-based herbicides in planted forests and the associated risks. Glyphosate is used infrequently in planted forests and at rates not exceeding 4 kg ha1. It is used within legal label recommendations and applied by trained applicators. While the highest risk of human exposure to glyphosate is during manual operational application, when applied according to label recommendations the risk of exposure to levels that exceed accepted toxicity standards is low. A review of the literature on the direct and indirect risks of operationally applied glyphosate-based herbicides indicated no significant adverse effects to terrestrial and aquatic fauna. While additional research in some areas is required, such as the use of glyphosate-based products in forests outside of North America, and the potential indirect effects of glyphosate stored in sediments, most of the priority questions have been addressed by scientific investigations. Based on the extensive available scientific evidence we conclude that glyphosate-based herbicides, as typically employed in planted forest management, do not pose a significant risk to humans and the terrestrial and aquatic environments.