Nonalcoholic fatty liver disease (NAFLD) — a metabolic-related disease resulting from insulin resistance, which is characterized by fatty liver degeneration of varying degrees in the absence of other factors of liver injury. Insulin resistance leads to enhanced lipolysis of adipose tissue with excessive release of fatty acids and their accumulation in the liver. The clinical significance of NAFLD consists in the possibility of simple steatosis progression to liver cirrhosis. There was studied the influence of individual care containing preparation of essential phospholipids enerliv on cytolysis indicators, blood lipids and morphostructural changes of the liver in patients with NAFLD. Examination of patients after the treatment showed reduced activity of transaminases, increased blood content of phospholipids fraction and decreased atherogenic factor. According to the findings of control sonographic studies, a reduction in the size of the left lobe of the liver was observed.