integrated synthesis of nucleotide and nucleosides influenced by amino acids
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integrated synthesis of nucleotide and nucleosides influenced by amino acids

;Irene Suárez-Marina;Yousef M. Abul-Haija;Rebecca Turk-MacLeod;Piotr S. Gromski;Geoffrey J. T. Cooper;Andrea Olivé Olivé;Stephanie Colón-Santos;Leroy Cronin
prostate cancer and prostatic diseases 2019 Vol. 2 pp. 1-8
181
surez-marina2019communicationsintegrated

Abstract

The direct glycosylation of ribose by nucleobases offers an intuitive route to nucleosides, but is known to be challenging under prebiotically plausible reaction conditions. Here, the addition of amino acids is shown to influence the product distribution, and a dynamic exchange of nucleobases between nucleosides and nucleotides is observed.

Keywords

chemistry

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DOI:
10.1038/s42004-019-0130-7
URL:
http://link.springer.com/article/10.1038/s42004-01...

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ID: 158480
Ref Key: surez-marina2019communicationsintegrated
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