the cross-bridge of skeletal muscle is not synchronized either by length or force step

the cross-bridge of skeletal muscle is not synchronized either by length or force step

;Enrico Grazi
Intertax 2015 Vol. 16 pp. 12064-12075
125
grazi2015internationalthe

Abstract

Force and length steps, applied to a muscle fiber in the isometric state, are believed to synchronize attached cross-bridges. This alleged synchronization facilitates the interpretation of the experiments. A rapid force step elicits an elastic response of the attached cross-bridges, followed by an isotonic phase. The decay of this second isotonic phase is of the first order. This excludes that the attached cross-bridges may decay all at the same time. The change of the X-ray interference distance during the second phase measures the stroke size only in the unrealistic case that the cross-bridges are and remain all attached. A rapid force step does not synchronize attached cross-bridges. The change of X-ray interference during the second phase does not measure the stroke size. These conclusions significantly change the picture of the mechanism of skeletal muscle contraction.

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