The role of Langerhans cells in the pathogenesis of vitiligo is as yet unresolved. Ultrastructurally, these cells are identified by the presence of Birpeck granules, but at times this morphological marker is missed during′ sectioning. Identification of Langerhans cells was done by monoclonal antibodies and these were quantitated in the depigmented and the pigmented skin of seven vitiligo patients. Observations are in favour of autoimmunity being an aetiological factor for vitiligo.