Purpose The aim of the present study was to evaluate the safety of LASIK surgery in patients with posterior polymorphous corneal dystrophy. Patients and methods A total of 25 eyes of 13 patients with posterior polymorphous dystrophy with various refractive errors were selected for LASIK treatment and were followed up for 2 years after surgery. Results All eyes included in the study showed an improvement in unaided visual acuity with no postoperative complications. Conclusion LASIK can be a safe procedure in patients with posterior polymorphous dystrophy and proper selection criteria.