This study aimed to assess the effect of four intracanal medicaments on pull-out bond strength of fiber posts.A total of 65 single-rooted, single-canal teeth were selected and decoronated. Root canals were prepared and after rinsing were randomly divided into five groups ( = 13). G: calcium hydroxide (CH), G CH plus chlorhexidine (CH+CHX), G: triple antibiotic paste (TAP), G: double antibiotic paste (DAP) were applied in the canals in the four groups. The control group (G) received no medicament. After 4 weeks, the medicaments were rinsed off and the canals were filled with gutta-percha. Post space was then prepared in root canals for the placement of glass fiber posts and self-adhesive cement (Panavia F2). After cementation, they were subjected to pull-out bond strength test.Data were statistically analyzed using one-way analysis of variance and Tukey test.The pull-out bond strength values were significantly different in the groups ( < 0.001). The highest values of bond strength were seen in G, G, and G (359.97 ± 81.26, 333.79 ± 98.96, 309.27 ± 78.07), respectively. There was no significant difference between G and G ( = 0.75).The results showed that CH, CH+CHX, and TAP enhanced the pull-out bond strength of fiber post to root canal wall as compared to the control group.