To analyze the deformation characteristics and the change rule of flow stress of 2219 aluminum alloy at high temperatures and high strain rates,the dynamic as well as quasi-static tensile response of 2219 aluminum alloy were investigated by using split Hopkinson pressure test(SHPB) and universal test machine. The true stress-strain curves of 2219 aluminum alloy under different strain rates and temperatures were obtained. The results show that the temperature sensitivity of 2219 aluminum alloy is high and the flow stress decreases with the increase of temperature. When the strain rates are within the range of 1000-3000s^-1, the change of flow stress is not obvious. The parameters fitted by the Johnson-Cook model can predict well the flow stress.