A numerical simulation to investigate the water entry of half-half sphere which is hydrophobic on one hemisphere and hydrophilic on the other is performed. Particular attention is given to the simulation method based on solving the Navier-Stokes equations coupled with VOF (volume of fluid) method and CSF (continuum surface force) method. Numerical results predicted experimental results, validating the suitability of the numerical approach to simulate the water entry problem of sphere under different wetting conditions. Numerical results show that the water entry of the half-half sphere creates an asymmetric cavity and “cardioid” splash, causing the sphere to travel laterally from the hydrophobic side to the hydrophilic side. Further investigations show that the density ratio and mismatch of asymmetric in wetting condition affect the trajectory, velocity, and acceleration of the half-half sphere during water entry. In addition, the total hydrodynamic force coefficient is investigated as a result of the forces acting on the sphere during water entry dictated by the cavity formation.