The existence and development of organizations depends on achievement of requisite holistic efficiency and effectiveness of their operations and bahaviour. But in theory (of organization and management) and business practice do not exist common understanding of efficiency and effectiveness, their relations and sinergies. When we try to investigate their definitions and relations we must take into account problems of many conflicts, which reflect their “different non-optimalty (unsuitability, inapproapriateness)”. This contribution discusses three theses: 1) how to more (requisitely) holistically understand relations between efficiency and effectiveness in the frame of business (its working and functioning), 2) how to understand their relations from the viewpoint of conflicts, and 3) one can create solution to remove a problem of different conflicts between efficiency and effectiveness in business.